Senior Software Engineer, Site Reliability

About this opportunity:

Do you have what it takes to be a Freenomer? A “Freenomer” is a determined, mission-driven, results-oriented employee fueled by the opportunity to change the landscape of cancer and make a positive impact on patients’ lives. Freenomers bring their diverse experience, expertise, and personal perspective to solve problems and push to achieve what’s possible, one breakthrough at a time.

Our Site Reliability Engineering (SRE) team is a new and critical function at Freenome. As a founding member of the team, you’ll help define the culture and build the systems that keep our regulated, cloud-based production environments reliable as we transition from research to commercial operations. This is an opportunity to do meaningful engineering work that will directly save lives.

We value:

• Reliability as a product feature

• Continual improvement and learning

• Automate all the things!

• Technical simplicity and clarity

• Blameless postmortems and transparent communication

As a Site Reliability Engineer, you will help design, implement, and operate observability, reliability, and incident management systems and practices across our clinical lab systems and regulated commercial workloads. You’ll partner with engineering teams to define service-level indicators (SLIs), objectives (SLOs), and error budgets; build runbooks and operational playbooks; and develop the monitoring and automation needed to ensure that our systems are reliable and compliant. This will also include contributions to system code, Infrastructure deployments and automation.

This role is ideal for an engineer with experience running production workloads in the cloud, who is excited to build an SRE practice from the ground up in a regulated environment.

The role reports to the Director, Cloud Infrastructure.

What you’ll do:

• Define and implement observability practices (metrics, traces, dashboards, logs, alerts) for production systems.
• Partner with product, engineering, and lab teams to develop and maintain incident response playbooks and escalation procedures.
• Partner with engineering teams to define SLIs/SLOs and establish error budgets.
• Participate in on-call rotation for production systems, champion a focus on automation and self-healing.
• Contribute to production deployment and change-management processes that meet FDA and compliance requirements.
• Automate operational tasks, reducing manual intervention.
• Contribute to production systems and designs with the goal of improving reliability.
• Use Infrastructure as Code (IaC) to manage and deploy team owned infrastructure and subsystems
• Help build out the SRE practice.
• Work closely with engineering, product, and lab teams to understand service reliability needs.
• Partner with TPMs, RA/QA, and compliance stakeholders to align operational practices with regulatory requirements.
• Participate in cross-functional incident reviews and postmortems.
• Share knowledge and document operational standards for consistency and onboarding.
• Design and run fire drills / tabletop exercises as well as disaster recovery exercises
• Independently drive reliability improvements in scoped systems or services.
• Provide mentorship to peers on observability, incident management, and operational best practices.
• Help build and evolve Freenome’s reliability practices and contribute to team strategy discussions.

Must haves:

• Bachelor’s degree in Computer Science, Engineering, or equivalent experience.
• 5+ years in software engineering or Infra/DevOps/SRE roles (Python or Go preferred).
• Experience deploying cloud infrastructure via automation (e.g. Terraform, Pulumi, Bicep/ARM, etc.)
• Hands-on experience operating production workloads in cloud environments.
• Familiarity with Kubernetes (AKS, GKE, or EKS).
• Strong troubleshooting and root-cause analysis skills in distributed systems.
• Experience with observability platforms (e.g., DataDog, Prometheus/Grafana, OpenTelemetry).
• Ability to define and implement metrics, dashboards, and alerting.
• Demonstrated ability to work autonomously and own technical outcomes.
• Strong understanding of cloud Infrastructure and Networking architectures and automation.

Nice to haves:

• Experience supporting regulated environments (healthcare, biotech, financial).
• Familiarity with compliance-driven change management and release processes (FDA, HIPAA).
• Experience with incident management platforms (e.g., Incident.io, ServiceNow, Opsgenie, Pagerduty).
• Knowledge of CI/CD deployment strategies and change automation.
• Experience with both GCP and Azure cloud platforms.
• Interest in mentorship and system reliability practices at scale.

Benefits and additional information:

The US target range of our base salary rate for new hires is $131,325 - $189,525. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education. We invite you to check out our career page @ _freenome.com/job-openings/_for additional company information.

Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.

Applicants have rights under Federal Employment Laws.

• Family & Medical Leave Act (FMLA)
• Equal Employment Opportunity (EEO)
• Employee Polygraph Protection Act (EPPA)

California applicants please review the CCPA Notice at Collection here:

• California Consumer Privacy Act (CCPA)

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